Chronic non-atrophic gastritis with rumbling erosion, Helicobacter pylori-negative can choose a light diet and other dietary therapies, choose omeprazole, teprenone and other drugs for relief and treatment. 1. Diet therapy: daily recommended light diet, less salt and oil; avoid the intake of spicy hot pot fried skewers, ice cream, alcohol, cigarettes, coffee, pickles and other food intake, to avoid further damage to the gastric mucosa, aggravate gastric pain, bloating, nausea, vomiting and other symptoms. 2. Medication: (1) Gastric mucosal protectant: such as Rebapatide, aluminum thiosulfate, bismuth potassium citrate, bismuth pectin and other drugs can effectively protect the gastric mucosa, thus avoiding further erosion of gastric mucosa by gastric acid, food and so on. (2) Proton pump inhibitors: such as omeprazole, eplazole, lansoprazole, pantoprazole, etc., can covalently bind with the proton pump of the gastric wall cells and irreversibly partially inactivate the proton pump, thus effectively inhibiting the secretion of gastric acid and alleviating the symptoms of gastric pain, acid reflux and heartburn. Chronic non-atrophic gastritis with rumbling erosion, it is recommended that gastroscopy to clarify the nature of the rumbling lesion, Helicobacter pylori-negative recommended timely medical attention to clarify the diagnosis, targeted treatment. In addition, all of the above medications should be taken under the guidance of a doctor and should not be used without authorization.