Cranial repair is a common surgical procedure in neurosurgery. Titanium mesh is one of the most used materials in the field of neurosurgery to repair the skull, and many patients with skull defects choose to use titanium mesh to restore the skull to integrity. The duration of use of titanium mesh is determined by the patient’s postoperative recovery. Some patients with titanium mesh repair may not experience discomfort after surgery and the mesh is not exposed. In this case, it can be used essentially for life. In other cases, the cranial area repaired with a titanium mesh may become infected or deformed by external forces, resulting in exposure, months or years after surgery. In such cases, the patient may be faced with the problem of replacing the material, and it is recommended that the patient go to the hospital for symptomatic treatment in the first instance, and then further consider the issue of material replacement at the discretion of the surgeon. Currently, the advanced and ideal material for skull repair is polyetheretherketone PEEK. This advanced material has been used in neurosurgery for a long time and has achieved ideal results in clinical practice.PEEK material is able to replicate the defective part of the human skull and reconstruct the design based on CT data through advanced 3D printing technology to match the defective area and meet the high demand of patients for perfect restoration of the defective area.The good histocompatibility of PEEK material, its stable chemical properties, the modulus of elasticity, and cortical bone, even in the event of collision, will not depress or deform, playing a crucial role in cranial bone repair surgery. We are now widely performing peek cranioplasty, an advanced and mature technology that integrates advanced peek material implants with the concept of aesthetic plastic surgery, which can achieve lifelong use through a single repair, with more outstanding results in terms of aesthetic appearance.