The difference between hemolytic jaundice and cholestatic jaundice can be shown in terms of etiology, pathogenesis, and clinical manifestations. 1. Etiology: (1) hemolytic jaundice: caused by hemolysis, divided into: ① congenital: hereditary spherocytosis, marine anemia and so on. ② Acquired: paroxysmal sleep hemoglobinuria, serosanguineous disease and so on. (2) Cholestatic jaundice: caused by cholestasis, divided into ① intrahepatic: parasitic diseases, viral hepatitis, etc. ② extrahepatic: cholestasis, viral hepatitis, etc. Extrahepatic: choledocholithiasis, tumor, etc. 2. Pathogenesis: (1) hemolytic jaundice: a large number of erythrocytes are destroyed, forming a large amount of unconjugated bilirubin, which exceeds the ability of hepatocytes to take up, conjugate and excrete, so that the unconjugated bilirubin in the blood exceeds the normal level, and jaundice occurs as a result. (2) Cholestatic jaundice: bile duct dilatation caused by bile duct obstruction leads to the rupture of small bile ducts and capillary bile ducts, resulting in the backflow of bilirubin from bile into the blood and the increase of direct bilirubin in the blood, thus causing jaundice. 3. Clinical manifestations: (1) Hemolytic jaundice: the skin and mucous membranes are light lemon color, not accompanied by skin itching. Acute can be accompanied by different degrees of hemoglobinuria (soy sauce color or tea color), chronic can be accompanied by splenomegaly. (2) Cholestatic jaundice: the skin and mucous membranes are dark yellow, and those with complete obstruction of the bile ducts are dark yellow or even yellow-green, accompanied by itching of the skin, bradycardia, dark urine, and lightened feces, or even white clay-colored. There are many other differences between the two, such as different changes in the indicators of laboratory tests. As soon as jaundice is detected, immediate medical attention is recommended.