Colon cancer chemotherapy takes different amounts of time depending on the chemotherapy regimen. For the FOLFOX regimen, one chemotherapy session takes 2 to 3 days, and a course of treatment is 14 days. For XELOX regimen, one chemotherapy session takes 14 days and one course of treatment is 21 days. 1. FOLFOX regimen: a course of treatment consists of intravenous oxaliplatin, calcium folinate on the first day, followed by 24-48 hours of fluorouracil pumping. The length of time depends on the different regimens, there are FOLFOX4 regimen or FOLFOX6 regimen. A regimen is 14 days. 2. XELOX regimen: If XELOX regimen is chosen, oxaliplatin infusion is needed on day 1, followed by oral capecitabine. It takes about 14 days to take oral capecitabine and 7 days of rest after finishing the medication, a course of treatment is 21 days. 3. FOLFIRI regimen: Irinotecan hydrochloride injection and calcium folinate injection are given intravenously for 2 hours on day 1, and fluorouracil injection is given by continuous intravenous infusion for 46-48 hours. A course of treatment is 14 days. The choice of specific chemotherapy regimen should be decided by professional physicians in combination with the patient’s specific condition. Patients should adjust their mindset and actively cooperate with the treatment in order to reap the best prognosis.