The coldness of the body during fever is the result of the upward shift of the thermoregulatory point of the body by the action of the thermogenic source on the temperature control center during the rising phase of fever temperature. During the rising phase of fever, the thermogenic source acts on the hypothalamus temperature control center, causing the thermoregulation point to move upward, and the brain receives instructions to increase heat production and decrease heat dissipation by means of muscular trembling and contraction of the pores of the skin. Due to the contraction of skin pores, touching the skin will feel cold and shivering. When the body temperature continues to rise to a certain stage, the temperature center through the regulation, so that the skin pores expansion, muscle tremor to do less work, so that the heat production is reduced, the body temperature is maintained at a certain level, at this time touching the forehead body surface skin will feel hot, hot. If you take fever-reducing drugs orally at this time, fever-reducing drugs inhibit prostaglandin synthesis, reduce heat production, so that the skin pores dilate, sweating increases and body temperature decreases, to achieve antipyretic effect. When the body fever and chills, it is recommended to go to the hospital in time to improve the examination and diagnosis, and timely treatment.