Can lobular hyperplasia of the breast become cancerous? Can lobular hyperplasia of breast become cancerous? Lobular hyperplasia is the most common breast disease in women, can lobular hyperplasia become cancerous? When does it become cancerous? How to distinguish lobular hyperplasia from breast cancer? This is a question that has long puzzled doctors and patients. Although patients suffering from lobular hyperplasia may have various symptoms and their symptoms will be relieved with appropriate medication, the shadow that lobular hyperplasia may turn into cancer in the future can never be eliminated and they are under great psychological pressure, which affects their work and life. As a doctor, we are afraid of mistakenly treating breast cancer as lobular hyperplasia and delaying the disease. 1. We should have a basic understanding of the nature and development process of lobular hyperplasia. We have already introduced that lobular hyperplasia is neither inflammation nor tumor, but a physiological hyperplasia and incomplete restoration resulting in poor or disordered breast tissue structure. Therefore, it is inappropriate to treat lobular hyperplasia as a pre-cancerous lesion. 2.Lobular hyperplasia can have different pathological stages in the process of development, and can be divided into three major categories according to the degree of epithelial hyperplasia: mild, high and atypical hyperplasia. Mild mammary gland hyperplasia instrument shows an increase in the number of ductal epithelium and mesenchyme, mammary epithelial cells still maintain the basic features and structure of normal epithelial cells; with the increase in the level of ductal epithelial cells, glandular epithelial cells to the ductal lumen or pile up in sheets, into irregular mesh, the degree of cell hyperplasia is far more obvious than mild hyperplasia; but the hyperplastic epithelial cells still maintain benign features, still visible myoepithelial cells The presence of myoepithelial cells and the integrity of the basement membrane make such hyperplasia a high degree of hyperplasia. If the highly hyperplastic epithelial cells show obvious anisotropy, varying cell size, abnormal nucleus and cytoplasm ratio, chromatin concentration, loss of polarity, and nuclear division phase, but myoepithelial cells are still present, this is atypical hyperplasia. In the past, some people thought that lobular hyperplasia of breast would become cancerous and designated the disease as pre-cancerous lesion. Only patients with highly hyperplastic ductal epithelium and atypical hyperplasia may become cancerous, and not all patients with atypical hyperplasia will definitely become cancerous in the future, because the vast majority of lobular hyperplasia will not become cancerous. It is worth noting that sometimes it is difficult to diagnose early breast cancer as lobular hyperplasia and delay treatment, and more often than not, lobular hyperplasia is diagnosed as cancer, which causes psychological stress and worry to patients. In conclusion, lobular hyperplasia is a common disease of the breast and should be followed up regularly. Those with obvious symptoms should be given appropriate treatment, and attention should be paid to differentiate it from breast cancer during the follow-up.