Keshan disease is a specific type of cardiomyopathy, called Keshan disease because it is found in Keshan County, Heilongjiang Province, China. Clinical manifestations: Patients mainly present with acute and chronic cardiac insufficiency, cardiac enlargement, arrhythmias and embolism of organs such as brain, lung and kidney. According to its onset and duration, it can be divided into acute Creutzfeldt-Jakob disease, subacute Creutzfeldt-Jakob disease, chronic Creutzfeldt-Jakob disease, etc. Among them, acute Creutzfeldt-Jakob disease can present critical symptoms and serious symptoms such as cardiogenic shock and sudden death; another part of patients have damaged heart structure but no obvious symptoms. Etiology: The etiology of Keshan disease is not fully understood, according to epidemiological investigation, it may be related to low selenium, in addition to nutritional status, viral infection and other factors. Current status: After decades of prevention and treatment, Keshan disease has basically disappeared in China. Treatment: Like other causes of heart failure, the treatment of Creutzfeldt-Jakob disease focuses on prevention of onset, prevention of attacks and improvement of symptoms; in addition, active prevention of factors that may cause Creutzfeldt-Jakob disease, such as low selenium, malnutrition and infections. Creutzfeldt-Jakob disease, once a serious disease that threatened for a while, has now largely disappeared through the joint efforts of the government and medical personnel. The prevention and treatment of Keshan disease brings us certain inspiration: actively search and cause and actively treat, many diseases are preventable and curable.