Soreness and fatigue in the stomach may be caused by acute and chronic colitis, rectal tumor lesions, ulcerative colitis and so on. 1. Acute and chronic colitis: if the patient’s abdomen is cold, or after eating unclean food, it will lead to inflammatory lesions in the intestinal mucosa, and the patient will have the feeling of fatigue in the abdomen, accompanied by abdominal pain and diarrhea. 2. Rectal neoplastic lesions: if tumor cells invade the rectal mucosa, it will lead to neoplastic or ulcerative changes in the rectum, resulting in a feeling of acidity and fatigue in the stomach, accompanied by poor defecation, bleeding and other phenomena. 3. Ulcerative colitis: due to immune function disorders, resulting in ulcerative lesions of the rectal and colonic mucosa, leading to a feeling of fatigue and bloating, accompanied by mucus, pus and blood stools. There are many other reasons for the acidity and fatigue in the stomach, and it is recommended that patients go to regular hospitals for consultation and relevant examinations, and according to the specific results of the examination, make a clear diagnosis, and take targeted therapeutic measures.