Total bilirubin and indirect bilirubin indicators are considered to be high due to physiological factors, drug factors, may also be cirrhosis, hemolytic anemia and other diseases caused by the disease need to be under the guidance of the doctor to carry out targeted treatment, such as general treatment, drug therapy, etc.; physiological factors caused by the need to adjust the lifestyle, drug factors caused by the need to consider the discontinuation of medication. 1. Physiological and medication factors: staying up late, irregular lifestyle, strenuous exercise can cause high total bilirubin and indirect bilirubin indexes, at this time, we should avoid staying up late, strenuous exercise, and maintain good living habits. 2. Disease factors: Cirrhosis should be prohibited from drinking alcohol in daily life, avoid taking hepatotoxic drugs, such as isoniazid and so on, can use reduced glutathione, silymarin and other drugs treatment. Hemolytic anemia needs to be treated according to the cause, such as blood transfusion reaction caused by the need to stop blood transfusion and drip sodium bicarbonate, etc., can also use methylprednisolone, cyclophosphamide and other drugs. 3. Drug factors: Isoniazid, pyrazinamide and other drugs can cause high total bilirubin and indirect bilirubin, which can be gradually recovered after stopping the drugs as prescribed by the doctor. After eliminating physiological factors, it is recommended to go to the hospital and ask the doctor to make a judgment and follow the doctor’s instructions for treatment and medication.