The penis is hard when you fall asleep and soft when you wake up, if it is a normal reaction, no special treatment is needed, temporary observation can be. If it is caused by genital inflammation, abnormal blood flow in the penis and other factors, general treatment and medication are needed. 1. Normal reaction: under normal circumstances, there may be falling asleep penis erection, wake up in the morning penis will become soft, mostly due to emotional, hormonal changes caused by sleep. If there is no other adverse reaction, there is no need for special treatment, temporary observation can be. 2. Genital inflammation: such as glans, prostatitis, epididymitis and other diseases, easy to cause the penis can not be normal erection, usually with frequent masturbation. You need to quit the habit of masturbation in time and use antibiotics reasonably. For bacterial infection, you can take cefixime and levofloxacin orally; for fungal infection, you can take itraconazole orally. 3. Abnormal penile blood flow: mainly refers to the lack of penile blood flow, resulting in penile spongiosum can not be normal erection, easy to cause penile weakness. Sildenafil citrate can be taken orally to expand blood vessels and improve the nitric oxide content of the penile corpus cavernosum. It is recommended to observe for a period of time, if the long-term inability to normal erection, affecting normal sexual intercourse, should consult a professional physician in time, and combined with the cause of targeted treatment, so as to avoid unauthorized use of drugs.