After surgical resection in early stage of gastric impression cell carcinoma, postoperative adjuvant chemotherapy is also recommended for stage I patients due to the high malignant degree of this subtype; for stage II patients, adjuvant chemotherapy is often needed to prolong the survival period of the patients, which needs to be decided according to the specific conditions. Gastric impression cell carcinoma is a pathological type of gastric cancer with a high degree of malignancy. The occurrence of the disease is mostly related to the mutation of e-calmodulin gene, and the prevalence of the disease is higher in young and middle-aged women. The treatment of early gastric cancer is mainly surgical resection, and due to its high malignant degree, postoperative chemotherapy can achieve better therapeutic effect. Commonly used surgical methods are radical surgery, etc. Commonly used chemotherapy regimen is 5-fluorouracil combined with platinum, which should be applied under doctor’s guidance.