The general closed treatment of pyriformis syndrome includes glucocorticoid closed treatment, botulinum toxin closed treatment, lidocaine closed treatment and so on. 1. Glucocorticoid closure therapy: glucocorticoid is the commonly used closure therapy drugs for pyriformis syndrome, mainly including methylprednisolone, prednisone, betamethasone, etc., mainly injected under ultrasound guidance, which is a good treatment effect for relieving acute pain. 2. Botulinum toxin closed treatment: Botulinum toxin can effectively inhibit the release of acetylcholine from the nerve endings to avoid muscle relaxation and paralysis, and is usually injected under ultrasound guidance, which has a good therapeutic effect on pyriformis syndrome. 3. Lidocaine closure therapy: Lidocaine is a local anesthetic, which can also be used to treat pyriformis syndrome. The above drugs should be used under the guidance of a doctor.