Esophageal cancer is esophageal cancer. Intermediate stage moderately differentiated squamous cell carcinoma of esophagus can be treated with comprehensive treatment methods such as surgery, radiotherapy, chemotherapy and endoscopic treatment, and patients should follow the doctor’s instructions to standardize the treatment. Patients with intermediate stage moderately differentiated squamous cell carcinoma of esophageal cancer can be resected by surgery, which may also be combined with lymph node dissection, digestive tract reconstruction and other surgical methods. Chemical drugs can be assisted after surgery, and the main drugs include cisplatin and paclitaxel. Radiation may also be used locally to kill cancer cells, such as the method of three-dimensional conformal radiotherapy. In addition, in middle and late stage esophageal cancer, obstruction can be approached through endoscopy, and common ways include endotest tube stent placement, endoscopic cancer ablation, etc., which can improve the survival rate of patients to a certain extent. It should be noted that, besides anti-tumor therapy, patients with esophageal cancer need to pay attention to nutritional support therapy in the whole treatment, including both enteral nutrition and parenteral nutrition. Patients with middle-differentiated squamous cell carcinoma in the middle stage of esophageal cancer can improve the symptoms and prolong the survival period after active and effective treatment. It is recommended that patients should carry out standardized treatment in time.