Hypoproteinemia in patients with advanced liver cancer is one of the manifestations of decreased synthesizing function of liver function when liver cancer is in advanced stage, and its 1-year survival rate is not more than 10%, and the survival period of most patients is only about 3 months. Liver is the place to synthesize protein. In patients with advanced liver cancer, the liver loses the ability to synthesize protein, which will cause protein lowering, and if it is not timely, it is easy to have other complications, such as hepatic ascites, malnutrition and other problems. For patients with mild hypoproteinemia, if albumin supplementation can be carried out in time to correct the hypoproteinemia, patients with advanced liver cancer may extend to more than half a year; For patients with moderate to severe hypoproteinemia, it will aggravate the patient’s condition, cause problems such as liver ascites malnutrition and infection, and together with other conditions caused by advanced malignant tumors, the patient’s life expectancy is often about 3 months time. Patients with advanced liver cancer, should go to the hospital in time and actively cooperate with doctors for treatment to maximize the survival time and improve the quality of patients’ survival.