The best and most effective way to kill H. pylori is to use quadruple therapy. Bismuth quadruple therapy is currently recommended as the primary empirical H. pylori eradication regimen. It includes bismuth, a proton pump inhibitor, and two antibiotics. A classic bismuth quadruple regimen, for example, consists of a proton pump inhibitor, bismuth, amoxicillin, and clarithromycin. For patients who fail the first eradication treatment, the doctor can choose another one among the remaining treatment options for remedial treatment after six months. For those who are resistant to multiple antibiotics, drug sensitivity test can be done before treatment to choose the sensitive antibiotics, and for patients who have failed the repeated treatments and need to continue the treatment, the doctor will evaluate the patient individually and holistically. Generally through the standardized medication for eradication of H. pylori under the guidance of a doctor, H. pylori infection can be cured, but it can still be re-infected if no attention is paid to dietary hygiene and lifestyle habits.