Hepatitis B surface antibody and hepatitis B surface antigen are both tests of the hepatitis B triple system, and their significance is mainly for hepatitis B surface antibody, which is formed by the body’s autoimmune response after the hepatitis B vaccination in normal people. After the formation of hepatitis B surface antibody, if the test result is positive and the titer is more than 10mIU/ml, it is considered to have autoimmune protection mechanism and the patient will not be infected with chronic viral hepatitis B. For hepatitis B surface antigen, if the hepatitis B triple system is positive, the patient is considered to be infected with hepatitis B virus, and it is necessary to combine other items in the hepatitis B triple system to see whether the patient is a major or minor triple. If the patient is a minor triple-positive, if the liver function is normal, the patient can continue to be observed. If the patient is a major triple-positive, consider that there is a replication of the virus, and if there is a combination of elevated glutathione transaminase, then consider that the patient has liver function damage, in the window of viral replication, need to actively consider antiviral treatment.