Lasting generally refers to male sex life time delay. All drugs have side effects, there is no such thing as a drug without side effects. Sex life delaying drugs include topical local anesthetics or oral time-delaying drugs. However, whether the use of side effects is different from person to person, and can not say that there are no side effects. 1. external local anesthetic: more commonly used is lidocaine, dacronine, etc.. Through the way of local anesthesia to reduce the glans and penile surface of the sensitive nerves, to achieve the effect of delay. Its main side effect is the numbness of the penis, affecting the experience of sexual life; part of the population may also be allergic to it, appearing red and itchy skin and so on. 2. Oral delay drugs: the more commonly used is Dapoxetine, also known as 5-hydroxytryptamine reuptake inhibitor. Its mechanism of action is to selectively block the reuptake of 5-hydroxytryptamine and delay ejaculation, clinically this drug is also commonly used to treat anxiety disorders. The side effects of Dapoxetine are headache or dizziness in some people, and nausea in others. The use of drugs should be carried out under the guidance of a doctor, do not blindly use drugs, so as not to delay the condition or cause adverse reactions.