When you wake up in the morning and find edema, you need to rule out bilateral edema or unilateral edema. If it is unilateral edema, then you need to rule out whether it is local inflammation, trauma, compression, as well as mosquito bites, allergies, and so on. If the edema is bilateral, then you need to consider systemic diseases, the most common are heart disease and rheumatic system disease and kidney disease. Rheumatic system diseases, in addition to bilateral edema, there may be bilateral joint stiffness relieved after activity, the most common is rheumatoid arthritis. If bilateral edema occurs in the hands, accompanied by bilateral eyelid edema and bilateral lower limb edema, the most common consideration is renal disease, when the foam in the urine can be increased, and other signs and symptoms of renal disease can appear accordingly. If bilateral edema is accompanied by palpitations after activity, arrhythmia or other palpitations, especially palpitations after exertion, then it needs to be considered as a cardiac system disease. Therefore, waking up in the morning with edema and hand swelling needs to be judged specifically according to different situations.