Hypothyroidism is a group of hypometabolic syndromes caused by low concentrations of thyroid hormones in the blood due to various causes. The main clinical manifestations of hypothyroidism are: i. Mucinous edema, mainly puffiness of the face and eyelids, fear of cold, little or no sweating, fatigue and weakness, unresponsiveness, lip and tongue enlargement, etc. Second, hypothyroid patients can affect the heart, forming hypothyroid heart disease, pericardial effusion, etc. Third, hypothyroidism affects the skeletal motor system leading to hypothyroid myopathy, manifested as muscle weakness or increased muscle enzyme profile. Fourth, hypothyroidism can cause slowing down of lipid, especially cholesterol metabolism, forming hypercholesterolemia. Fifth, severe hypothyroidism can lead to mucinous edema coma, which is an endocrine disorder and needs to be actively treated.