Blockage of both nostrils in turn may be a symptom of chronic simple rhinitis, which is related to alternate congestion of both turbinates and body position. Chronic simple rhinitis is a chronic inflammation of the nasal cavity with swelling of the nasal mucosa and increased secretions as the main symptoms. Nasal congestion and increased nasal discharge are the main symptoms. Chronic simple rhinitis nasal congestion is characterized by intermittent and alternating. Intermittent: nasal congestion decreases during the day, warmth, labor or exercise, and worsens during sleep, cold, and sitting still. During exercise, the whole body autonomic nerve is excited, the nasal mucosa vasoconstriction, nasal congestion is reduced. Alternating: Nasal congestion is heavier when lying down, better ventilation on the upper side and heavier nasal congestion on the lower side when lying on the side. It is related to the elevation of internal jugular venous pressure when lying down. Lower side nasal congestion after lateral recumbency may be related to the autonomic reflexes of the shoulder and arm. Treatment can generally use intranasal decongestants, such as Seroquel hydrochloride nasal drops, naphazoline hydrochloride nasal drops and other vasoconstriction, to improve the symptoms of nasal congestion, the general use of medication does not exceed 7 days. The two nostrils take turns to blockage suggests that the patient timely hospital consultation, follow the doctor’s prescription medication treatment.