Clinically, generalized soreness and weakness after waking up is mainly seen in the following diseases: 1, soreness due to muscle strain caused by overexertion or activity, at this time, it is recommended to take proper rest and minimize activities, and physical therapy such as acupuncture and massage is also feasible. 2, rheumatic diseases, such as rheumatoid arthritis, can also cause generalized soreness, at this time The corresponding immunological examination should be carried out at the hospital, and symptomatic treatment should be given after clear diagnosis, or oral treatment with non-steroidal anti-inflammatory drugs such as diclofenac sodium.