The treatment of duodenal descending mucosal polyps includes drug therapy, endoscopic resection, and general symptomatic treatment. 1. Medication: when the polyp is small, there are usually no obvious symptoms, and when it grows, it may show bloating and constipation, which can be treated with targeted gastrointestinal stimulants under the guidance of a doctor, such as mosapride and domperidone. 2. Endoscopic resection: usually should pay attention to regular endoscopic examination, observe the polyp changes, if the polyp increases rapidly or has a tendency to malignant transformation, should go to the gastroenterology department in a timely manner, in the endoscopic polyp resection, so as not to cause other effects. 3. General symptomatic treatment: in life, the diet should pay attention to light, greasy indigestible and spicy stimulating food to eat less. To have good habits, avoid staying up late, appropriate exercise. Duodenal descending polyps should go to the regular hospital for timely treatment.