Most patients with Rett syndrome can survive to adulthood, with an average age of about 40, depending on the patient’s own physical condition and family financial conditions. Rett syndrome is a disease that seriously affects the psychomotor development of the affected children, more female patients, patients can not take care of their own life, the clinical manifestations of the patient’s gradual decline in mental ability, and then there are communication disorders, language disorders, stereotyped behavior of the hands, hand function is reduced or disappeared, and may even be unable to walk independently. There is no specific treatment for Rett’s syndrome, and it is usually necessary to strengthen nursing care and symptomatic treatment. For children with convulsive seizures, antiepileptic drugs are given. Most patients survive into adulthood, with an average age of around 40 years. Patients with Rett syndrome are advised to seek prompt medical attention and treatment under a doctor’s supervision.