Pain in the liver area in the middle of the night but not during the day may be due to hepatitis or fatty liver. 1. Hepatitis: Hepatitis is usually caused by viral infections, and drug or alcohol damage to the liver may also cause hepatitis to appear. Hepatitis is often accompanied by pain in the liver area and loss of appetite. Viral hepatitis requires antiviral treatment under doctor’s guidance. If hepatitis is caused by drug or alcohol damage to the liver, it is necessary to suspend the related drugs or quit drinking immediately. 2. Fatty liver: Fatty liver is usually related to drugs, malnutrition or hereditary factors. In severe cases, symptoms such as loss of appetite, nausea and vomiting may occur. Usually, fatty liver can be improved by diet control and proper exercise. Patients who experience pain in the liver area in the middle of the night and no pain during the day should consult a doctor and follow the doctor’s instructions for treatment.