Renal function deterioration in patients with diabetic renal failure tends to be faster, and if combined with hypertension, renal function deterioration is more rapid. Diabetic patients have a higher incidence of vascular complications, often with retinopathy and cardiovascular disease. Once creatinine clearance is <10-15 ml/min, hypertension will be difficult to control, which can lead to fundus hemorrhage and fatal cardiovascular events. Compared with non-diabetic end-stage renal failure, its anemia, water-sodium retention and systemic toxicity symptoms are more significant. Therefore, patients with diabetes mellitus should be dialyzed earlier, and dialysis treatment should be started when the glomerular filtration rate decreases to 15-20 ml/min; if the patient's blood pressure can be easily controlled and his/her nutritional status is good, it can be relaxed to start dialysis when the glomerular filtration rate decreases to 10-15 ml/min; however, patients who are malnourished, with intractable edema, and with severe hypertension need to be dialyzed earlier.