Breast pain without menstruation is usually abnormal in women aged 50. Breast pain without menstruation may be caused by breast diseases, such as breast hyperplasia, mastitis and breast tumors, and the cause should be identified and treated in time. 1. Breast hyperplasia: Breast pain without menstruation accompanied by breast pain in a 50-year-old patient may be caused by breast hyperplasia because the patient’s breast will be stimulated to a certain extent after the gland hyperplasia, at which time there will be obvious pain. Do not repeatedly squeeze with your hands, and it is recommended to do breast ultrasound and other auxiliary examinations in order to make a clear diagnosis and treatment. 2. Mastitis: The absence of menstruation along with breast pain can also be caused by mastitis. If the patient’s nipple is damaged and then inflamed, it will cause hard nodules in the breast and then pain. If the nipple is damaged and inflamed, it will cause a hard knot in the breast and then pain. Chronic mastitis can result in a palpable lump in the breast, which is hard and painful to the touch. 3. Breast tumors: Breast pain may be caused by breast tumors, because the gradual increase of the tumor may affect the surrounding nerves, thus causing local swelling and pain and neuropathic pain in the breast. It is recommended to seek medical treatment as soon as possible to identify the cause of the disease and treat it in time to avoid delaying the disease.