For hypertensive patients, it is dangerous if the blood pressure is always high and cannot be lowered. 1. Long-term hypertension will cause cerebral blood vessels to undergo ischemia and degeneration, forming microaneurysms, and once ruptured, cerebral hemorrhage can occur, endangering life. At the same time, it will also promote cerebral atherosclerosis, which will induce cerebral thrombosis. 2. Long-term hypertension will lead to high pressure load on the heart, causing left ventricular hypertrophy and dilatation, becoming hypertensive heart disease, left ventricular hypertrophy will lead to subendocardial myocardial ischemia. 3. Long-term persistent hypertension will make the glomerular capsule pressure, glomerular fibrosis, atrophy, renal arteriosclerosis, resulting in renal parenchyma ischemia and renal units continue to decrease, and finally lead to renal failure. If the blood pressure has been high can not come down, need to go to the hospital in a timely manner, under the guidance of the doctor to use antihypertensive drugs, do not pay attention to, so as not to cause adverse consequences.