Pain in the medial depression of the knee joint after running is mostly seen in medial collateral ligament injury, medial meniscus injury, etc. Different causes of treatment are also different, and the clinic needs to give general treatment, physical therapy, drug treatment and surgical treatment. 1. Medial collateral ligament injury: medial collateral ligament strains are common, patients are advised to reduce knee activities, local cold compresses can be applied in the acute stage, ibuprofen and other painkillers can be given when the pain is severe, partial rupture can be given to the external fixation of the plaster, and ligament repair is often needed in case of complete rupture. 2. Medial meniscus injury: after the injury, it is recommended to reduce the activities of the knee joint, can not stand and walk for a long time, not to engage in strenuous exercise and weight bearing. Cold compresses should be applied in the acute stage, hot compresses in the relieving stage, and painkillers such as diclofenac sodium can be given to those with severe pain. Those with severe injury and ineffective conservative treatment need to be given meniscectomy, repair surgery and so on. It is recommended that patients go to the hospital, improve the auxiliary examination, in order to clarify the condition, the professional physician for treatment, there are adverse reactions and contraindications to drugs, so you need to use under the guidance of a professional physician.