Clonazepam and lorazepam both belong to the benzodiazepine sedative-hypnotic drugs, the mechanism of action of the two drugs is the same, the efficacy of the drug with the individual’s physical condition, and drug sensitivity and so on, can not be generalized. Both drugs are benzodiazepine sedative-hypnotic drugs, through the non-selective and Υ-aminobutyric acid-benzodiazepine receptors to play a role, can be used for the treatment of insomnia, anxiety, antiepileptic, anticonvulsant and so on. Clonazepam is available in tablets and injections, and cannot be used for allergy to ingredients, glaucoma, pregnant women, newborns, severe hepatic and renal dysfunction, etc. It can cause hypokinesia, irritability, somnolence, etc., and long-term use of the drug has tolerance and dependence. Lorazepam is commonly used as an oral preparation, can not be used for severe myasthenia gravis, allergy to the ingredients, acute angle-closure glaucoma, pregnant women, lactation, <12 children, etc., the common adverse reactions are sedation, vertigo, lethargy, etc., and long-term use of the drug will have dependence and tolerance. Both drugs are prescription drugs, should be taken in accordance with medical advice, not self-medication, so as not to delay the condition.