You should not take cephalosporin the day after drinking alcohol one day. Drinking alcohol the day before and taking cephalosporin the next day can easily lead to disulfiram-like reaction, and it is recommended to take cephalosporins at least 3 days after drinking alcohol. Alcohol in wine is ethanol, ethanol is mainly metabolized by the liver’s ethanol dehydrogenase enzyme, it is difficult to completely metabolize alcohol from the body within 1 day, the residual ethanol in the body and cephalosporins will have a disulfiram-like reaction, which is manifested as a persistent headache, dizziness, chest tightness and discomfort, nausea and vomiting. Cephalosporins such as cefdinir will inhibit the activity of ethanol dehydrogenase, inhibit the metabolism of ethanol in the body, resulting in the accumulation of ethanol in the body, and continue to produce symptoms of alcoholism. This inhibition is therefore similar to disulfiram, referring to it as a disulfiram-like reaction. Individuals also differ in the rate of metabolism of alcohol, and the longer the interval between taking alcohol and cephalosporins, the better; patients are advised to take cephalosporins after at least 3 days of drinking.