People often say impotence and premature ejaculation together, but medically impotence and premature ejaculation are two different diseases, and the causes and treatments are not the same. Impotence, also known as male erectile dysfunction, is a condition in which the hardness of the penis erection is insufficient for vaginal penetration when attempting to have sexual intercourse, or the hardness of the penis erection is not maintained long enough to complete a satisfactory sexual life. The main treatment methods are: General treatment: change poor lifestyle, prevention and control of high-risk factors, such as increased exercise, weight loss and drugs that can cause erectile dysfunction (ED), active treatment of diabetes, hypertension of the original law of the disease. Endocrine therapy: such as testosterone secretion deficiency caused by primary testicular disease or secondary to pituitary, hypothalamic disease and middle-aged and elderly late gonadal dysfunction can take testosterone supplementation therapy. Psychotherapy: For patients with obvious psychosomatic diseases, psychosexual therapy can be performed alone or in combination with other treatment modalities. However, psychosexual treatment is time-consuming and its efficacy is uncertain. Pharmacotherapy: The first line of therapy is phosphodiesterase 5, an enzyme widely distributed in penile cavernous tissue that hydrolyzes cyclic ornithine phosphate (cGMP). Inhibition of PDE5 activity can block cGMP hydrolysis and increase its concentration, inducing relaxation of penile vascular and cavernous sinus smooth muscle, which can lead to an increase in penile arterial blood flow and induce penile erection. The current highly selective PDE5 inhibitors, sildenafil, tadalafil and vardenafil, etc. Vacuum negative pressure device therapy: clinically belongs to the second line of treatment. When negative pressure device is used, a negative pressure ring is placed at the root of the penis to stop blood return, and the negative pressure acts on the penile corpus cavernosum to attract blood into the penis, resulting in passive erection. Penile cavernosal drug injection therapy: also a second line of therapy. Vasodilating drugs such as prostaglandin E1, poppyrine, and phentolamine are injected into the penile corpus cavernosum to induce erection through local vasodilating effects. However, the dosage of drugs used and the method of drug injection must be determined under medical supervision to avoid serious complications. Surgical treatment with penile erectile device implantation: clinically, it is a third-line therapy. There are two types of erectile devices to choose from, flexable (semi-rigid) and expandable erectile devices (two, or three piece set). Most patients prefer the three-piece expandable erector because it provides a more “natural” erection, but has the disadvantage of mechanical failure and other complications, and is more expensive. The two-piece prosthesis has a lower incidence of mechanical failure and is simpler to implant. Premature ejaculation is the disharmony of sexual intercourse that occurs when the penis is inserted into the vagina and the woman has not yet reached orgasm, while the man’s intercourse time is shorter than 2 (5) minutes and he ejaculates early. Its treatment is mainly psychotherapy, especially behavioral therapy. Through general psychological treatment, patients can be taught about sex, help them to relieve their worries and reduce anxiety and tension, and can eliminate fear and anxiety before sexual intercourse by teaching them to master muscle relaxation. Therefore, impotence and premature ejaculation are not a disease and have different treatments respectively. There are more treatment options available for impotence, and clinical ladder treatment can be used to choose different programs according to the degree of the condition, while premature ejaculation is generally based on psychological treatment.