Insufflation of the middle and lower lobes of the right lung with solid metaplasia may be caused by pneumonia, tuberculosis, lung cancer, etc. It can be treated with general treatment, azithromycin and other medications. 1. Pneumonia: Cough, sputum, fever, wheezing, etc., which may appear as right middle and lower lobes of lungs with distensibility and solid shadow. Cough can use aminoglutethimide to reduce phlegm; wheezing can use aminophylline to calm the wheezing; if it is mycoplasma infection, azithromycin and other anti-inflammatory can be used; fever can be reduced with ibuprofen. 2. Tuberculosis: mainly coughing, coughing up sputum, sputum with blood, etc., may appear in the right lung middle and lower lobe expansion incomplete and solid shadow. Active TB needs to be treated with anti-tuberculosis drugs for at least six to nine months, depending on age and overall drug use. Early, regular, full, moderate, and combined medication is usually prescribed, including isoniazid and rifampicin. 3. Lung cancer: mainly manifested as cough, sputum, blood in sputum, dyspnea, partly accompanied by fever, etc. Lung cancer of the middle and lower lobes of the right lung may appear as incomplete expansion of the middle and lower lobes of the right lung with solid shadow. Treatment mainly includes bed rest, reducing oxygen consumption and strengthening nutrition; at the same time, molecular targeted drugs such as bevacizumab can be used. Surgery is the first choice of treatment for lung cancer, which is applicable to patients with early stage of lung cancer and some middle stage. Surgery for early lung cancer is more effective. There are other possibilities, such as chronic obstructive pulmonary disease, etc. It is recommended to find out the cause of the lung cancer in time and treat it accordingly. The above medications should be taken in accordance with doctor’s prescription.