IgG4-associated cholangitis is asymptomatic in the early stage, and some patients may show biliary system manifestations of IgG4-associated disease and other organ involvement. 1. Biliary system manifestations: IgG4-related sclerosing cholangitis (IgG4-SC) is a rare disease, which is more common in elderly male patients, and is asymptomatic in early stage, which is mainly detected by physical examination. Some patients show symptoms of involvement of the bile ducts, which manifest as obstructive jaundice, itchy skin, abdominal discomfort, steatorrhea, weight loss and other non-specific symptoms. 2. Involvement of other organs: pancreas is the most common organ involved, such as new-onset diabetes mellitus. In addition, salivary gland enlargement and retroperitoneal fibrosis can also be complicated. When the patient has the above symptoms, there is no need to worry too much, and he should go to the hospital in time for further examination and clear diagnosis.