There are two main types of drugs to reduce atrial aqueous production, one is β-adrenergic receptor blockers and the other is carbonic anhydrase inhibitors. β-adrenergic receptor blockers are commonly used, such as 0.5% timolol eye drops, 0.5% betacarbam, and betaxolol eye drops, which are used to lower intraocular pressure (IOP) by inhibiting atrial aqueous production 1-2 times a day, but the magnitude of their lowering of IOP is limited, and their pressure-lowering effect is weakened by long-term application. However, the magnitude of IOP lowering is limited and the effect of IOP lowering diminishes after long-term application. Another category is carbonic anhydrase inhibitors, including topical brinzolamide eye drops, also reduces aqueous humor production, side effects are mainly mild eye discomfort, abnormal taste, bitter mouth, etc., allergic to sulfonamides should be prohibited. Can also be systemic oral carbonic anhydrase inhibitors, such as acetazolamide, but there are kidney stones, sulfonamide drug allergy to be prohibited, the common side effects are fatigue, nausea, feeling abnormal, electrolyte disorders, urinary tract stones, personality changes.