If you have been taking glucosamine sulfate for a month and are not taking any other medications, you should suspect that the symptoms are caused by a chronic allergy to the medication, so you can stop taking the medication first and observe whether the symptoms are relieved. Patients who take glucosamine sulfate normally experience only mild gastrointestinal discomfort and allergic symptoms. Patients with hepatic or renal insufficiency may have symptoms of hepatic or renal impairment, but rarely will they experience generalized pain. Therefore, if the pain is relieved after stopping the drug, it is considered to be caused by drug allergy. If the pain is not relieved even after stopping the medication, it is necessary to consider whether the generalized pain is caused by other reasons, such as fatigue or cold stimulation, resulting in transient inflammation of the soft tissues of the limbs, or muscle aches and pains due to cold or fever, and it is necessary to go to a regular hospital for timely consultation.