Due to the decrease of ovarian function, the secretion of estrogen and progesterone will be reduced during menopause, which will lead to a series of symptoms, mainly in the areas of neuropsychiatric, cardiovascular and skeletal. Among them, neuropsychiatric symptoms are more common, such as menopausal headache specific treatments are: First, general treatment, can be given to glutamine 20mg oral, 3 times / day, in order to regulate the plant nerve dysfunction. Second, psychological treatment, due to women’s emotional vulnerability easily caused by anxiety, depression, emotional weakness, psychological factors will be manifested in the physical symptoms of headache, psychological analysis, treatment, if necessary, appropriate antidepressant medication, such as Derexin. Third, hormone replacement therapy, if the symptoms are not relieved after the above treatment, hormone replacement therapy should be given under the condition of assessing the risk, and complications such as cerebral thrombosis should be avoided.