The treatment of severe mitral valve insufficiency has two main aspects: internal medicine and surgical treatment. 1. Internal medicine treatment: acute mitral valve severe closure insufficiency often appear heart failure performance, even shock occurs in severe cases, so can use arterial dilators to reduce the pressure of the left atrium and reduce mitral regurgitation, such as isosorbide mononitrate, captopril, metoprolol and so on. In case of chronic severe mitral valve insufficiency, angiotensin-converting enzyme inhibitors can be used to reduce the volume of the left ventricle, such as captopril, perindopril and so on. It is necessary to choose the appropriate drugs under the guidance of specialized doctors. 2. Surgery: Surgery is the most fundamental measure for treating severe mitral valve insufficiency. Surgery includes mitral valvuloplasty, mitral valve replacement and so on, the former is applicable to the case of less severe valve damage, and the latter is applicable to the case of more severe valve damage. It is recommended to consult a professional doctor for treatment of severe mitral insufficiency.