Irbesartan and amlodipine benzenesulfonate have different compositions, different mechanisms of action of the drugs, and different adverse reactions and contraindications. 1. Different components: Irbesartan’s main component is Irbesartan, and Amlodipine besylate’s main component is Amlodipine, there is a significant difference between the two components of the drug. 2. Different mechanisms of action: the main effect of Irbesartan is to inhibit angiotensin II receptors, with vasodilatory effects. Amlodipine’s main mechanism of action is to inhibit the inward flow of calcium ions, relieve vascular tension, dilate the arteries to play a role in lowering blood pressure, both have vasodilatory effect, but the mechanism of action of the two have obvious differences. 3. Adverse reactions and contraindications are different: Irbesartan’s adverse reactions are flu-like symptoms, nausea, vomiting, cough, elevated blood potassium, etc., allergic to the drug components, lactating women during pregnancy, severe renal insufficiency patients are prohibited. Adverse effects of amlodipine benzenesulfonate include lower extremity edema, dry stools, tachycardia, etc. It is contraindicated in patients who are allergic to the components of the drug and have severe hypotension. Whether it is Irbesartan or amlodipine benzenesulfonate, the use of both need to be carried out under the guidance of a professional physician, and should not be used without authorization.