The incubation period of HFMD is 3-5 days, with prodromal symptoms such as low-grade fever, general malaise, abdominal pain, etc. Within 1 to 2 days, painful corn to green bean-sized blisters appear in the mouth, pharynx, soft palate, buccal mucosa, tongue, and gums, surrounded by a red halo, and break down into small ulcers, often with salivation and refusal to eat due to pain. The incubation period is 3 to 5 days, with prodromal symptoms such as low fever, general malaise, abdominal pain, etc. Within 1 to 2 days, painful blisters of corn to green bean size appear on the oral cavity, pharynx, soft palate, buccal mucosa, tongue, and gums, surrounded by a red halo, and break down into small ulcers, often with salivation and refusal to eat due to pain. The rash also appears on the hands and feet, with a variable number of blisters on the dorsal side of the hands and feet and on the dorsal edge of the fingers (toes), around the nails, and on the palmoplantar area, and also on the buttocks and near the anus, and occasionally on the trunk and extremities, drying up and fading after a few days, without itching or pain. Individual children may develop generalized papules and blisters, accompanied by aseptic meningitis, encephalitis, myocarditis and so on. Generally, the whole course of the disease is about 5-10 days, and most of them can heal spontaneously with good prognosis. Routine examination: terminal blood leukocyte count is reduced or normal; urine and stool are generally not abnormal. A throat swab or stool specimen can be sent to the laboratory for virus testing, but it takes 2 to 4 weeks for the virus test to produce results.