Hepatobiliary nuclear degeneration is an inherited metabolic disease, and the latest treatment options, including gene therapy, hepatocyte or stem cell transplantation are currently in the research phase and have not yet been applied in the clinic. The main treatments include general therapy, drug therapy and liver transplantation. Hepatomegaly is characterized by liver disease, neuropsychiatric abnormalities, decreased copper blue protein, elevated urinary copper and positive corneal pigment ring. Early diagnosis and standardized copper treatment can improve the prognosis, otherwise it can progress to end-stage liver disease and lead to severe motor dysfunction. 1. General treatment: low-copper, promote copper excretion diet, increase high-quality protein intake, high vitamin diet, reduce fat intake, moderate intake of carbohydrates. Prohibit the intake of animal offal, blood, nuts and legumes, shellfish and chocolate. 2. Drug therapy and liver transplantation therapy: mainly including penicillamine, zinc preparation (zinc gluconate), etc.. For patients with advanced cirrhosis and liver failure, liver transplantation can be considered. Hepatomegaly patients are recommended to be actively treated, although other latest treatments are currently in the research stage and have not yet been applied to the clinic, but through the existing treatment programs can maximize the control of the disease and slow down the progress of the disease. It is recommended that patients should seek medical advice if they are unwell, and that medications should be used under the guidance of a physician.