H. pylori triple and quadruple therapy are not good or bad, research has concluded that the efficacy of quadruple therapy is more certain, but you need to follow the doctor’s advice and choose in conjunction with your own situation. Triple therapy refers to a proton pump inhibitor combined with two antibiotics to treat H. pylori, such as omeprazole + amoxicillin + metronidazole, etc. Quadruple therapy refers to a proton pump inhibitor + two antibiotics + a bismuth agent to treat H. pylori infection, such as omeprazole + amoxicillin + metronidazole + bismuth potassium citrate. Theoretically, because of the addition of bismuth to the quadruple therapy, it enhances the strength of the action of the acid-suppressing drugs and has a stronger killing effect on H. pylori, but its because of the increased dosage of the drug, it may involve more side effects, and therefore you need to follow the doctor’s advice and choose in conjunction with your own situation. If you are infected with H. pylori, you should carry out standardized treatment under the guidance of your doctor, and avoid choosing therapies and medications on your own to avoid serious consequences.