Hypoproteinemia is not an independent disease, but rather the result of a negative nitrogen balance due to various causes, and can occur in the course of various diseases. Inadequate intake and excessive loss can cause a decrease in plasma protein. The main clinical manifestations are signs of malnutrition, such as the patient’s increasing weight loss, poor appetite, fatigue and weakness, decreased physical strength, memory loss, decreased body resistance, and frequent dizziness. Hypoproteinemia can cause a decrease in the osmotic pressure of plasma, causing excessive water to be retained between tissues, resulting in swelling, and in severe cases, pleural fluid and ascites.