Swelling of the hand from an IV may be caused by needle stick injury, needle dislocation, inappropriate drug dosage, bacterial infection and other reasons. It is recommended to seek the help of healthcare professionals to determine the cause of swollen hands and whether treatment is needed. 1. Needle-stick injury: If venepuncture is performed improperly and repeated puncture damages the blood vessel wall and the surrounding soft tissues, the local inflammatory reaction may be caused by the trauma, resulting in symptoms of redness, swelling, heat and pain. At this time, the puncture should be stopped, the injection position can be changed, and the injury site can generally heal by itself, or be treated with hot compresses to promote swelling. 2. Needle ectopic: In the process of IV, if the needle is ectopic due to positional changes, so that it is not in the blood vessels but in the subcutaneous, the drug input subcutaneous can cause local edema, and the nitrogen mustard and other drugs with strong irritation, but also on the surrounding subcutaneous tissues to produce chemical inflammatory reaction. Need to replace the injection site, the swollen parts to be hot compresses, external magnesium sulfate solution and other treatments. 3. Inappropriate drug ratio: If the concentration, pH value and osmotic pressure of the infused drugs are not appropriate, it can stimulate the infused vein and cause chemical phlebitis and hand swelling. Need to replace the drug treatment. If you have swollen hands on IV, it is recommended to seek medical help to avoid adverse reactions.