654-2, or scopolamine, intestinal obstruction is a contraindication to this drug, and its use may aggravate the condition of intestinal obstruction. Scopolamine is an anticholinergic drug, which can relieve smooth muscle spasm caused by acetylcholine, and has a relaxing effect on gastrointestinal smooth muscle. Intestinal obstruction includes many types, such as mechanical intestinal obstruction, the peristalsis of the intestinal tube above the obstruction site is strengthened, and the use of scopolamine can inhibit its peristalsis so as to achieve the effect of pain relief. However, at the same time, it may mask the situation of intestinal strangulation, intussusception and other conditions that lead to blood flow obstruction, resulting in a more serious condition, so scopolamine should not be used for antispasmodic and analgesic treatment. In paralytic intestinal obstruction, intestinal motility is slowed down and intestinal contents accumulate in the intestines leading to abdominal distension. The relaxing effect of scopolamine on gastrointestinal smooth muscle not only fails to relieve pain, but may also aggravate the condition, so scopolamine cannot be used. Therefore, under normal circumstances, scopolamine can not be used for the treatment of intestinal obstruction, it is recommended to follow the doctor’s instructions to avoid adverse consequences.