Ovarian signs of premature aging can be regulated and restored through general treatment, hormone supplementation therapy and assisted reproductive technology, which need to be analyzed specifically. 1. General treatment: Premature ovarian failure may cause estrogen level to decrease, thus causing bone metabolism abnormality, which can be regulated by eating more calcium food such as fish, pork ribs, etc., and also by supplementing Vitamin D through more sun exposure. 2. Hormone supplementation therapy: When ovarian premature failure occurs, the level of estrogen decreases, leading to autonomic nervous system dysfunction. At this time, estrogen can be supplemented through estradiol, estriol and other medications to alleviate uncomfortable symptoms. 3. Assisted Reproductive Technology (ART): If a woman with premature ovarian failure has the need to prepare for pregnancy, she can use assisted reproductive technology (ART) to improve the success rate of pregnancy. If there is premature ovarian failure, it is recommended to use medication under the guidance of a doctor, not blindly self-medication to avoid adverse effects.