Blood pressure of 180 is generally defaulted to a systolic pressure of 180 mmHg (diastolic pressure rarely reaches 180). It is recommended to start with nifedipine extended-release tablets 1 (10mg/tablet), and change to 2 (20mg/tablet) when monitoring poor blood pressure control. The use of antihypertensive drugs generally comply with the minimum effective dose, depending on the blood pressure situation gradually increase the amount of drugs and the principle of combination of drugs, can effectively reduce the incidence of dizziness, panic and other adverse reactions caused by too rapid lowering of blood pressure, and the patient can have a certain degree of acclimatization process. Systolic blood pressure of 180mmHg, belonging to hypertension level 3, under normal circumstances, the efficacy of only one kind of drug is not good, and should not increase the dosage of nifedipine extended-release tablets is too large, should be used jointly as soon as possible with other types of antihypertensive drugs, so as to improve the effect of blood pressure lowering and do not increase the incidence of adverse reactions. Nifedipine belongs to calcium channel blockers, can be used alone or in combination with other types of antihypertensive drugs. It is suitable for all types of hypertension, especially for elderly patients, and can be used in patients with combined diabetes, coronary heart disease or peripheral vascular disease. Adverse reactions include hypotension, increased heart rate, facial flushing, headache, and lower extremity edema. It should be used with caution in those with heart failure or tachycardia, and is contraindicated in those with unstable angina and those who are allergic to the drug. Other types of commonly used antihypertensive drugs include diuretics (e.g., hydrochlorothiazide, indapamide, etc.), beta receptor antagonists (e.g., metoprolol, atenolol, labetalol, etc.), angiotensin-converting enzyme inhibitors (e.g., captopril, perindopril, etc.), and angiotensin II receptor antagonists (e.g., valsartan, irbesartan, ali-sartan, etc.). Suffering from high blood pressure also needs to seek medical attention as soon as possible, and the above medications need to be used in accordance with the doctor’s instructions.