A positive mitochondrial type 2 is a result of a serum liver function test that suggests the possibility of a current immune liver disease. A positive mitochondrial type 2 on serum liver function tests is indicative of a current immune liver disease, such as autoimmune hepatitis, primary biliary cirrhosis, or sclerosing cholangitis, which may cause a positive mitochondrial type 2. If mitochondrial type 2 positivity is the result of an immune liver disease, the patient may experience itchy skin, loss of appetite, and, if the disease is further aggravated, jaundice, which results in yellowing of the skin and sclera, may develop. If the cause of mitochondrial type 2 positivity is to be analyzed accurately, blood biochemistry, mitochondrial DNA analysis, and pathological biopsy are necessary to identify the cause of the disease and then target the treatment.