Quadruple therapy can remove H. pylori in the vast majority of cases. H. pylori is a special class of bacteria that is resistant to a strong acidic environment and is the only bacteria that can survive in the stomach, which can irritate the gastric mucosa and lead to damage to the gastric mucosa, forming erosive gastritis, gastric ulcers, and can even induce gastric cancer. Quadruple therapy is a common treatment for H. pylori. Quadruple therapy mainly consists of two antibiotics, plus a proton pump inhibitor, plus a bismuth agent. Antibiotics are often chosen from penicillins, quinolones, aminoglycosides, and nitroimidazoles. Proton pump inhibitors mainly include omeprazole, rabeprazole, etc. Bismuth agents often include colloidal bismuth pectin, bismuth aluminate and so on. The course of administration should be up to ten to fourteen days. In the clinic there does exist a small number of patients with drug resistance, at this time should be replaced with sensitive antibiotics, for another quadruple therapy to kill H. pylori treatment.