Diltiazem can be combined with atorvastatin. The former is a non-dihydropyridine calcium antagonist used for preventing angina attacks in coronary heart disease and lowering blood pressure, while the latter is used for lowering blood lipids and preventing atherosclerosis, and is recommended to be used under medical supervision. It has been confirmed by medical research that Diltiazem can be used in combination with atorvastatin and other antihypertensive drugs, and there is a possibility of adverse reactions, but if the dosage is correctly controlled, there will be no adverse effects, and it is generally safe, and can be used in strict compliance with medical advice. Atorvastatin and diltiazem are both metabolized in the body by the same drug enzyme, cytochrome P450 3A4 (referred to as “drug enzyme 3A4”), and will have an effect on each other. Diltiazem is an inhibitor of Pharmacokinase 3A4, so there is a possibility of adverse reactions with atorvastatin. However, safety and effectiveness can be achieved if the doses of the two medications are matched appropriately, e.g., by paying attention to lower doses when using atorvastatin. Although Diltiazem can be used in combination with Atorvastatin, patients should never add the medication at their own discretion, and should take the medication correctly in strict accordance with the doctor’s requirements.