Taking cephalosporin 12 hours after drinking alcohol will produce a disulfiram-like effect, which refers to the chemical reaction in the body between the drug components in cephalosporin and the ethanol in alcohol. Firstly, in mild cases, it will cause skin allergy, such as rash, red rash, maculopapular rash, itchy skin, fusion into patches, and even skin-like changes such as vesicles and oozing. Second, in severe cases, chest tightness, shortness of breath, palpitations, precordial discomfort, and arrhythmia may occur. Thirdly, in severe cases, dizziness, headache, jet vomiting, transient disorders of consciousness or even unconsciousness may occur. Fourth, the most severe cases may show clinical symptoms of anaphylaxis. Within 7 days after drinking alcohol, taking cephalosporin more or less will cause a disulfiram-like reaction, such as taking cephalosporin 12 hours after drinking alcohol will cause a mild to moderate disulfiram-like reaction. However, for some patients with alcohol allergy or cephalosporin hypersensitivity, the symptoms of disulfiram-like reaction will be significantly and obviously aggravated, and it is necessary to go to hospital immediately for symptomatic treatment and disposal to avoid affecting or delaying the condition.